Design of Multi-Wavelength Low-Level Laser Therapy Device for Assisting Bone Reconstruction Applications
AbstractOne of the main focus areas in human body reconstruction is the regeneration of bone tissue in different body zones by using various reconstruction applications. In the last two decades, different efforts have been undertaken for developing new bone reconstruction methods, and supporting techniques for stimulating bone healing mechanisms. It has been shown that during different Bone Reconstruction Applications (BRA), the presence of laser light could enhance the bone regeneration and healing mechanisms, while shortening the treatment time and improving the quality of newly formed bone tissue. The application of Low-Level Laser Therapy (LLLT) has recently been used for new bone reconstruction applications in different body parts, including the tibia, fibula, femur, humerus, radius, and mandible. It was shown that by applying a low-power laser light during the bone healing procedure in different treatments, an improved quality of regenerated bone tissue was evident, while accelerating bone healing mechanisms. However, only a few studies have been performed with regard to the development of specific LLLT devices for such advanced bone reconstruction procedures. More research needs to be done towards developing an ideal LLLT device to be used in different bone reconstruction techniques. The purpose of this research is to design a novel multi-wavelength LLLT device with controllable laser light intensity. In addition, by using such a mechanism, generating the laser light in single- and multi-wavelengths in predetermined working sequences is possible. The design specifications and simulation results have shown that the proposed system is functional while meeting all required specifications in terms of generating a single- or multi-wavelength laser light, with controllable power intensity. Therefore, in future developments, the proposed system could be used during BRA for assisting the treatment.
 El-Ghannam, A., "Bone Reconstruction: From Bioceramics to Tissue Engineering." Expert review of medical devices, Vol. 2(1), pp. 87-101, 2005.
 Huang, X., et al., "Physical Stimulations for Bone and Cartilage Regeneration." Regenerative engineering and translational medicine, Vol. 4(4), pp. 216-237, 2018.
 Shuai, C., et al., "Physical Stimulations and Their Osteogenesis-Inducing Mechanisms." Int. J. Bioprint, Vol. 4, pp. 138-158, 2018.
 Freddo, A.L., et al., "Influence of a Magnetic Field and Laser Therapy on the Quality of Mandibular Bone During Distraction Osteogenesis in Rabbits." Journal of Oral and Maxillofacial Surgery, Vol. 74, No. 11, pp. 2287. e1-2287. e8, 2016.
 Tsumaki, N., et al., "Low-intensity Pulsed Ultrasound Accelerates Maturation of Callus in Patients Treated with Opening-wedge High Tibial Osteotomy by Hemicallotasis". JBJS, Vol. 86, No. 11, pp. 2399-2405, 2004.
 Abd-Elaal, A., et al., "Evaluation of the Effect of low-Level Diode Laser Therapy Applied during the Bone Consolidation Period Following Mandibular Distraction Osteogenesis in the Human." International journal of oral and maxillofacial surgery, Vol. 44, No. 8, pp. 989-997, 2015.
 Hagiwara, T. and W.H. Bell, "Effect of Electrical Stimulation on Mandibular Distraction Osteogenesis". Journal of Cranio-Maxillofacial Surgery, Vol. 28, No. 1, pp. 12-19, 2000.
 Qokakoglu, S., F. Aydogan, and B. Aydm, "Low Level Laser Therapy in Orthodontics/Dusuk Doz Lazcrlcrin Ortodonti Alaninda Kullanimi." Meandros Medical and Dental Journal, Vol. 19, No. 2, pp. 99-106, 2018.
 Skondra, F.G., et al., "The Effect of Low-Level Laser Therapy on Bone Healing After Rapid Maxillary Expansion: a Systematic Review". Photomedicine and laser surgery, Vol. 36, No. 2, pp. 61-71, 2018.
 Gurler, G. and B. Gursoy, "Investigation of Effects of Low Level Laser Therapy in Distraction Osteogenesis." Journal of stomatology, oral and maxillofacial surgery, Vol. 119, No. 6, pp. 469-476, 2018.
 Dos Santos Santinoni, C., et al., "Influence of Low-level Laser Therapy on the Healing of Human Bone Maxillofacial Defects: A Systematic Review". Journal of Photochemistry and Photobiology B: Biology, Vol. 169, pp. 83-89, 2017.
 Taha, S.K., et al., "Effect of Laser Bio-Stimulation on Mandibular Distraction Osteogenesis: An Experimental Study." Journal of Oral and Maxillofacial Surgery, Vol. 76, No. 11, pp. 2411-2421, 2018.
 Miloro, M., J.J. Miller, and J.A. Stoner, "Low-level Laser Effect on Mandibular Distraction Osteogenesis". Journal of oral and maxillofacial surgery, Vol. 65, No. 2, pp. 168-176, 2007.
 Olate, S.M. and Z.S. Haidar, "NanoBioTechnology-guided Distraction Osteogenesis and Histiogenesis". Journal of Oral Research, Vol. 6, No. 6, pp. 142-144, 2017.
 Kitoh, H., et al., "Transplantation of Culture Expanded Bone Marrow Cells and Platelet Rich Plasma in Distraction Osteogenesis of the Long bones". Bone, Vol. 40, No. 2, pp. 522-528, 2007.
 Karu, T., "Photobiology of Low-power Laser Effects." Health phys, Vol. 56, No. 5, pp. 691-704, 1989.
 Cakarer, S., et al., "Acceleration of Consolidation Period by Thrombin Peptide 508 in Tibial Distraction Osteogenesis in Rats." British Journal of Oral and Maxillofacial Surgery, Vol. 48, No. 8, pp. 633-636, 2010.
 Hübler, R., et al., "Effects of low-level laser therapy on bone formed after distraction osteogenesis." Lasers in medical science, Vol. 25, No. 2, pp. 213-219, 2010.
 Freddo, A.L., et al., "Effect of low-Level Laser Therapy After Implantation of Poly-L-Lactic/Polyglycolic Acid in the Femurs of Rats". Lasers in medical science, Vol. 24, No. 5, pp. 721-728, 2009.
 Tim, C.R., et al., "Effects of Low Level Laser Therapy on Inflammatory and Angiogenic Gene Expression During the Process of Bone Healing: A Microarray Analysis." Journal of Photochemistry and Photobiology B: Biology, Vol. 154, pp. 8-15, 2016.
 De Oliveira Gonçalves, J.B., et al., "Effects of Low-Level Laser Therapy on Autogenous Bone Graft Stabilized with a New Heterologous Fibrin Sealant". Journal of Photochemistry and Photobiology B: Biology, Vol. 162, pp. 663-668, 2016.
 Gomes, F., et al., "Low-level Laser Therapy Improves Peri-Implant Bone Formation: Resonance Frequency, Electron Microscopy, and Stereology Findings in a Rabbit Model." International journal of oral and maxillofacial surgery, Vol. 44, No. 2, pp. 245-251, 2015.
 Shakouri, S.K., et al., "Effect of low-Level Laser Therapy on the Fracture Healing Process". Lasers in medical science, Vol. 25, No. 1, pp. 73, 2010.
 Pretel, H., R.F. Lizarelli, and L.T. Ramalho, "Effect of low‐Level Laser Therapy on Bone Repair: Histological Study in Rats." Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery, Vol. 39, No. 10, pp. 788-796, 2007.
 Hatefi, S., et al., "Review of Automatic Continuous Distraction Osteogenesis Devices For Mandibular Reconstruction Applications." BioMedical Engineering OnLine, Vol. 19, No. 1, pp. 1-21, 2010.
 Hatefi, S., et al., "Continuous Distraction Osteogenesis Device with MAAC Controller for Mandibular Reconstruction Applications." Biomedical engineering online, Vol. 18, No. 1, pp. 43, 2019.
 Hatefi, K., et al., "Design of Laser-Assisted Automatic Continuous Distraction Osteogenesis Device for Oral and Maxillofacial Reconstruction Applications." Majlesi Journal of Electrical Engineering, Vol. 13, No. 4, pp. 135-145, 2019.
 Cerqueira, A., et al., "Bone Tissue Microscopic Findings Related to the Use Of Diode Laser (830etam) in Ovine Mandible Submitted to Distraction Osteogenesis." Acta cirurgica brasileira, Vol. 22, No. 2, pp. 92-97, 2007.
 Freddo, A.-L., et al., "A Preliminary Study of Hardness and Modulus of Elasticity in Sheep Mandibles Submitted to Distraction Osteogenesis and Low-Level Laser Therapy." Medicina oral, patologia oral y cirugia bucal, Vol. 17, No. 1, pp. e102, 2012.
 Korany, N.S., et al., "Evaluation of socket healing in irradiated rats after diode laser exposure (histological and morphometric studies)." Archives of oral biology, Vol. 57, No. 7, pp. 884-891, 2012.
 Cepera, F., et al., "Effect of a low-level laser on bone regeneration after rapid maxillary expansion." American Journal of Orthodontics and Dentofacial Orthopedics, Vol. 141, No. 4, pp. 444-450, 2012.
 Hatefi, S., O. Ghahraei, and B. Bahraminejad, "Design and Development of a Novel Multi-Axis Automatic Controller for Improving Accuracy in CNC Applications." Majlesi Journal of Electrical Engineering, Vol. 11, No. 1, 2017.
 Hatefi, S., O. Ghahraei, and B. Bahraminejad, "Design and Development of a Novel CNC Controller for Improving Machining Speed." Majlesi Journal of Electrical Engineering, Vol. 10, No. 1, pp. 7, 2016.
 Sharma, G., P. Mohindru, and P. Mohindru, "Simulation Performance of PID and Fuzzy Logic Controller for Higher Order Systems." Majlesi Journal of Mechatronic Systems, Vol. 5, No. 1, 2016.